Rev 18:4+5 came to mind this morning. It says:

And I heard another voice from heaven, saying, “Come out of her, my people, so that you will not be a partner in her sins and receive her plagues; for her sins (crimes, transgressions) have piled up as high as heaven, and God has remembered her wickedness and crimes [for judgment]".

I have two questions on that:
1. What does it mean to come out of her? Is it a physical move, a spiritual break, a break of dependence, etc.?
2. When should we come out? Is it only at that given time of the troubles or should we start breaking our dependencies earlier?