And another angel, a third, followed them, saying with a loud voice, "If anyone worships the beast and its image and receives a mark on his forehead or on his hand..."
Revelation 14:9

The Mark of the Beast probably isn't a physical mark at all, but is definitely something intrinsically tied to the worship of the beast and its image. God's commandments, the Sabbath, and his appointed times are a mark on the hands and foreheads of his people. If we are living in obedience to God's instructions, we aren't going to accidentally fall into worshipping the beast. We should be less concerned about taking "The Mark of the Beast" and more concerned about taking the Mark of YHWH.