Those who are in the flesh cannot please God.
Romans 8:8 ESV

It is impossible to please God if you refuse to keep his Law or to trust him. Such a person has either convinced himself that he is right in whatever he does, that the Torah no longer applies for whatever reason, or else that he can never understand, never do enough, learn enough, to please God. Either position betrays a lack of trust, and the faithless person becomes God's enemy regardless of how nice or kind he might be otherwise.