Greet also the church in their [Prisca and Aquila] house....
Romans 16:5 ESV

Rome was a very large city. If there were any significant number of believers, then there must have been multiple homes scattered across the area in which they were meeting. Prisca and Aquila hosted an assembly at their home in Ephesus, and having returned to Rome, now hosted an assembly there instead.

This should be the norm.