Genesis 4:17, “And Cain had relations with his wife, and she conceived and gave birth to Enoch. Then Cain built a city and named it after his son Enoch.” (This is a different Enoch than the son of Jared.) The first time the word for city is used is this verse and it is used in a very negative context. Whenever Cain or anything associated with him is mentioned in the Bible is always has a negative context.